Malegra DXT is composed of sildenafil and duloxetine and is employed in medicating erectile deficit (erectile dysfunction, or ED) aggravated by ejaculatory precocity (premature ejaculation, or PE). The drug is taken by mouth in anticipation of sexual activity.

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Malegra DXT is composed of sildenafil and duloxetine and is employed in medicating erectile deficit (erectile dysfunction, or ED) aggravated by ejaculatory precocity (premature ejaculation, or PE). The drug is taken by mouth in anticipation of sexual activity.

The two active substances of Malegra DXT mutually enhance each other, helping to overcome the symptoms of comorbid condition that are often diagnosed in men with compromised sexual health. The connection between erectile deficit and shortened intravaginal ejaculatory latency time (IELT) is traced in a large number of patients and can be explained by general problems with sexual functions.



  • Erectile dysfunction



Malegra DXT should not be used in patients less than 18 years of age, because – in this category of patients – the drug increases the risk of suicide attempts and hostility (aggression, oppositional behavior and anger). Since duloxetine contained in Malegra DXT can cause drowsiness and dizziness, driving and using machines is not recommended. Abrupt discontinuation of duloxetine treatment is not recommended as withdrawal symptoms may occur.



Headache is one of the possible side effects, which comes when the medicine is not taken according to the instructions in the package insert. Headache after Malegra DXT may be due to overdose, combination with alcohol or nitrites.

Even in the case of strict compliance with all the rules of administration, the present side effect can occur in 10% of cases, which makes it the most frequent side effect, possible after taking Malegra DXT. Dizziness occurs much less frequently and does not exceed 7% of cases.

Fewer users can develop such symptoms as drowsiness, migraine, ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, light-headedness, depression, insomnia. These occur in less than 1% of cases. It should be noted that the frequency of side effects decreases as the body becomes accustomed to the drug. Thus, during Carson’s research, the headaches at the start of the study were present in 10% of erectile dysfunction patients, but after the 16 weeks they decreased to less than 1%, the rate of dizziness was also decreased from 7% to less than 1%.

An important fact is that two thirds of patients during this study gradually increased the dose of Malegra DXT.

  • Most users (about 10%) report facial flushing.
  • Not frequent Malegra DXT side effects (less than 1%) are tachycardia, heartbeat sensation, low blood pressure, myocardial ischemia, heart failure, deviation in ECG results.
  • Rarely occurring (no more than in 0.5% of all registered cases) are atrial fibrillation and ventricular arrhythmia.

The effects of Malegra DXT associated with withdrawal can be as follows If duloxetine treatment is stopped abruptly, so-called withdrawal symptoms can occur. These symptoms include:

  • dizziness;
  • difficulty sleeping;
  • vivid dreams and nightmares;
  • headache;
  • feeling of restlessness;
  • agitation;
  • anxiety;
  • irritability;
  • myalgia;
  • tremor;
  • fatigue;
  • drowsiness;
  • nausea or vomiting;
  • diarrhea;
  • excessive sweating;
  • headache

Usually, these symptoms do not occur in severe form and disappear within a few days, but – should they occur – it is still necessary to inform the doctor.



Malegra DXT works best if it’s taken approximately one hour before sexual activity. To get an erection, you will need to be sexually stimulated. Doctors usually suggest taking 50 mg once per day, but the dosage can be decreased to 25 mg or increased to 100 mg if needed. Do not intake more than one dose every 24 hours. Malegra DXT cannot be taken at the same time as other medications used to treat male erectile dysfunction problems. You should not intake Malegra DXT with a high-fat meal, because it can reduce the effectiveness of the medication. Malegra DXT does not protect you from sexually transmitted diseases.



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Sildenafil citrate is the active ingredient in Malegra DXT and is available in a generic, unbranded tablet. Sildenafil and Malegra DXT are medically equivalent but Sildenafil is available at a much lower cost.

Generic medicines has the same composition and are equally effective and medically equivalent as the branded products but are available at a lower price. Generic manufacturers has to prove that they are medically identical to the branded product - i.e. they offer the strength, stability, same quality and effectiveness.

Generic medicines are required meet the same standards of safety, quality and efficacy as the branded medication. To get it market approved from the European Medicines Agency and MHRA, a generic medicine must be 'bioequivalent' to the originator product.

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